Human TCR (E2.5) recognizes Insulin precursor peptide (EAEDLQVGQVELGG) in the context of HLA-DQ2. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Human soluble TCR (E2.5). Please note that the activity is not guaranteed.

Specifications

Host Species
Human

Target
Insulin precursor

Species Reactivity
Human

Epitope
EAEDLQVGQVELGG

MHC
HLA-DQ2

Clone
E2.5

Type
Soluble TCR (ZIP-Fos/ZIP-Jun)

Related Disease
Others

TCR Expression Strategy
ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.

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