Recombinant Human Anti-KMT2D Soluble TCR (M9) (ZIP-Fos/ZIP-Jun) (CAT#: VS-0622-YF1920)
Human TCR (M9) recognizes KMT2D peptide (ALSPVIPLI) in the context of HLA-A*02:01. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Human soluble TCR (M9). Please note that the activity is not guaranteed.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/if_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_B_9_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_B_9_5.jpg
Figure 3 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_A_9_3.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_A_9_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_A_9_5.jpg
Figure 5 Testis
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_A_5_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35977/75127_A_5_6.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167548-KMT2D
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167548-KMT2D
Specifications
- Host Species
- Human
- Target
- KMT2D
- Species Reactivity
- Human
- Epitope
- ALSPVIPLI
- MHC
- HLA-A*02:01
- Clone
- M9
- Type
- Soluble TCR (ZIP-Fos/ZIP-Jun)
- Related Disease
- Kabuki syndrome
- TCR Expression Strategy
- ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.
Target
- Alternative Names
- Lysine Methyltransferase 2D; Myeloid/Lymphoid Or Mixed-Lineage Leukemia 2; Lysine (K)-Specific Methyltransferase 2D; Trinucleotide Repeat Containing 21; Lysine N-Methyltransferase 2D; ALL1-Related Protein; MLL2; MLL4; ALR; Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2; Histone-Lysine N-Methyltransferase MLL2
- Gene ID
- 8085
- UniProt ID
- O14686
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3999z | Mouse Anti-KMT2D Recombinant Antibody (clone 19A12) | WB, IP, ELISA | Mouse IgG2a, κ |
| VS7-0425-WR243 | Mouse Anti-KMT2D Recombinant Antibody (clone 3C8E11) | FC | Mouse IgG1 |
| VS7-0425-WR244 | Mouse Anti-KMT2D Recombinant Antibody (clone 1D10F6) | IHC, FC | Mouse IgG1 |
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