Recombinant Human Anti-MRGPRF Soluble TCR (AF11) (ZIP-Fos/ZIP-Jun) (CAT#: VS-0622-YF2002)
Human TCR (AF11) recognizes MRGPRF peptide (RLWEPLRVV) in the context of HLA-A2. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Human soluble TCR (AF11). Please note that the activity is not guaranteed.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nuclear membrane & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/1446_F1_4_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nuclear membrane & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/1446_F1_4_selected.jpg
Figure 2 IHC staining of human heart muscle
(Immunohistochemical staining of human heart muscle shows moderate positivity of the nuclear membrane in myocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/ihc_selected.jpg
(Immunohistochemical staining of human heart muscle shows moderate positivity of the nuclear membrane in myocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_B_7_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_8_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_8_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_8_5.jpg
Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_4_6.jpg
Figure 7 Endometrium
(Cells in endometrial stroma Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_B_4_3.jpg
(Cells in endometrial stroma Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_B_4_3.jpg
Figure 8 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28811/60283_A_9_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+, fHDF/TERT166, U-2197)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172935-MRGPRF
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172935-MRGPRF
Specifications
- Host Species
- Human
- Target
- MRGPRF
- Species Reactivity
- Human
- Epitope
- RLWEPLRVV
- MHC
- HLA-A2
- Clone
- AF11
- Type
- Soluble TCR (ZIP-Fos/ZIP-Jun)
- TCR Expression Strategy
- ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.
Target
- Alternative Names
- MAS Related GPR Family Member F; G-Protein Coupled Receptor 140; G-Protein Coupled Receptor 168; Mas-Related Gene F Protein; MAS-Related GPR, Member F; GPR140; GPR168; MRGF
- Gene ID
- 116535
- UniProt ID
- Q96AM1
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