A431, OVCAR3, BxPC3 and HT-29 (clone mAb2)-Aminocaproyl-MMAF ADC

CAT#: ADC-270CL

This ADC product is composed of an anti-A431, OVCAR3, BxPC3 and HT-29 antibody (clone mAb2) conjugated via Aminocaproyl linker to MMAF(mAb2-HCQ01-Aminocaproyl-MMAF). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Specifications

  • Antibody Overview
  • mAb2 (a Chimeric IgG1 Antibody) HCQ01
  • Clone
  • mAb2
  • Antibody Isotype
  • IgG1
  • Linker
  • Aminocaproyl
  • Drug
  • MMAF (Monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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