Mamu-A*02/Simian Immunodeficiency virus Nef protein (YTSGPGIRY) MHC Pentamer (CAT#: MHC-YC184)
MHC multimers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a Pentamer of peptide/MHC complex with SIV-derived peptide of YTSGPGIRY sequence covering 159-167 and Mamu-A*02 molecule. The peptide/MHC pentamer provided here is unlabeled or fluorescent labeled such as Biotin, R-PE, APC. And all of them are available in 50, 150 or 500 tests.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Specifications
- Allele
- Mamu-A*02
- Class
- Class I
- MHC Species
- Monkey
- Antigen
- Simian Immunodeficiency virus Nef protein
- Antigen Species
- SIV
- Peptide
- YTSGPGIRY
- Range
- 159-167
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Nef protein seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Nef protein probably involved in viral immune evasion mechanisms. In infected CD4+ T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules. Nef protein interferes with TCR signaling from the cell membrane and interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes.
- Alternative Names
- SIVgp7; nef protein
- Gene ID
- 1490008
- UniProt ID
- Q02840
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MHC Tetramer Products for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2659CQ | Recombinant Mouse Anti-SIV Nef Antibody (17) | ELISA, IHC, IF, WB, RIA | Mouse antibody |
| MRO-2660CQ | Recombinant Mouse Anti-SIV Nef Antibody (04-001) | WB, IF, IHC-P | Mouse antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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