Recombinant Mouse Anti-Peptide SIY Soluble TCR (C-Cys) (VS-0622-YF4949)
CAT#: VS-0622-YF4949
Mouse TCR recognizes Peptide SIY peptide (SIYRGYYL) in the context of H2-Kb. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.
Specifications
- Host Species
- Mouse
- Target
- Peptide SIY
- Epitope
- SIYRGYYL
- MHC
- H2-Kb
- Type
- Soluble TCR (C-Cys)
- TCR Expression Strategy
- C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.
Target
- Alternative Names
- Peptide SIY; SIYRGYYL
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Stable and Reliable Performance
I've been using this antibody for months, and its stability in my assays has been outstanding. Even with repeated freeze-thaw cycles, it maintains its functionality, which speaks volumes about its quality.
Great for T-Cell Research
This antibody is a game-changer in my lab for studying T-cell receptor interactions. It offers clear insights into the binding properties of T-cells with implicated peptides, advancing our understanding of T-cell immunobiology.
Easy to Integrate into Existing Protocols
Its design as a soluble TCR facilitates integration into our existing protocols without extensive modifications. This has saved us a lot of time and resources in method development.
High-Quality Research Tool
This antibody stands out in my experiments for its high sensitivity and specificity. The consistent results across different batches underscore its utility as a research tool.
Consistent Results Across Experiments
Whether in batch experiments or single assays, this antibody provides consistent results, essential for ensuring data accuracy and reproducibility in my research work.
Q&As
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What is the target of this antibody?
A: The target of this antibody is the Peptide SIY, specifically recognizing the SIYRGYYL epitope in the context of H2-Kb. This precision offers a valuable tool for researchers interested in studying specific immune responses.
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How does the C-Cys strategy affect the antibody's structure?
A: The C-Cys strategy enables the expression of the alpha and beta chains to form a heterodimer, enhancing its solubility by omitting the transmembrane and cytosolic regions. This design focuses on improving research outcomes by providing a more stable molecular structure.
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What research applications could benefit from using this antibody?
A: This antibody is particularly useful in research focusing on T-cell receptor interactions, antigen presentation, and studies of immune recognition. Its specificity makes it ideal for examining peptide-MHC interactions.
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How is stability ensured in this antibody design?
A: By employing the C-Cys strategy for forming heterodimeric TCRs, stability is achieved through the careful engineering of the molecular structure, minimizing degradation and aggregation risks.
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How does this antibody facilitate a better understanding of peptide-MHC interactions?
A: By using a defined peptide-MHC target, researchers can precisely map TCR engagements, influencing studies on immune tolerance, autoimmunity, and T-cell development.
View the frequently asked questions answered by Creative Biolabs Support.
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