Mouse TCR (BDC-10.1) recognizes pS3 peptide (SRLGLWVRME) in the context of H2 class II. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Mouse soluble TCR (BDC-10.1). Please note that the activity is not guaranteed.

Specifications

Host Species
Mouse

Target
pS3

Epitope
SRLGLWVRME

MHC
H2 class II

Clone
BDC-10.1

Type
Soluble TCR (ZIP-Fos/ZIP-Jun)

Related Disease
Type 1 diabetes (T1D)

TCR Expression Strategy
ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.

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