Recombinant Anti-CLCN7 Vesicular Antibody, EV Displayed (VS-0425-YC536)
CAT#: VS-0425-YC536
The Recombinant Anti-CLCN7 Vesicular Antibody, EV Displayed (VS-0425-YC536) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLCN7-expressed cells or tissues. CLCN7 belongs to the CLC chloride channel family, important in bone resorption. Mutations in CLCN7 cause osteopetrosis, presenting with overly dense bone due to defective resorption. Both recessive and dominant forms of osteopetrosis are associated with this protein.
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CLCN7
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Chloride voltage-gated channel 7
- Biological Process
- Antiport, Ion transport, Transport
- Introduction
- The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.
- Alternative Names
- CLC-7, CLC7, OPTA2, PPP1R63
- Gene ID
- 1186
- UniProt ID
- P51798
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Datasheet
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See other products for "CLCN7"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-214 | Recombinant Anti-human CLCN7 Antibody | WB, Dot, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-214-F(E) | Recombinant Anti-human CLCN7 Antibody Fab Fragment | ELISA, FacS, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-214-S(P) | Recombinant Anti-human CLCN7 Antibody scFv Fragment | FC, RIA, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-214 | Recombinant Human Anti-human CLCN7 Antibody | FC, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-214-F(E) | Recombinant Human Anti-human CLCN7 Antibody Fab Fragment | ELISA, WB, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-214-S(P) | Recombinant Human Anti-human CLCN7 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0923-WJ | Mouse Anti-CLCN7 Recombinant Antibody (clone HX2) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0923-WJ-S(P) | Mouse Anti-CLCN7 Recombinant Antibody (clone HX2); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0923-WJ-F(E) | Mouse Anti-CLCN7 Recombinant Antibody (clone HX2); Fab Fragment | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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