Recombinant Anti-CX3CL1 Vesicular Antibody, EV Displayed (VS-0425-YC519)
CAT#: VS-0425-YC519
The Recombinant Anti-CX3CL1 Vesicular Antibody, EV Displayed (VS-0425-YC519) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CX3CL1-expressed cells or tissues. CX3CL1 is the sole member of the CX3C chemokine subgroup, characterized by a specific cysteine arrangement. It functions as both a membrane-anchored and soluble chemotactic cytokine, interacting with the G-protein coupled receptor CX3CR1. CX3CL1 is implicated in diseases such as cancer and atherosclerosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26192/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in reaction center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26192/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40361/90576_A_8_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40361/90576_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40361/90576_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40361/90576_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40361/90576_A_5_6.jpg
Normal Tissue
Figure 8 Skin
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Langerhans Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40361/90576_B_9_1.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (EFO-21, HDLM-2, Hep G2, RPTEC TERT1, SK-BR-3)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000006210-CX3CL1
❮
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CX3CL1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-X3-C motif chemokine ligand 1
- Biological Process
- Cell adhesion, Chemotaxis, Host-virus interaction, Inflammatory response
- Molecular Function
- Cytokine
- Cellular Localization
- Plasma membrane
- Introduction
- This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections.
- Alternative Names
- ABCD-3, C3Xkine, CXC3, CXC3C, NTN, SCYD1
- Gene ID
- 6376
- UniProt ID
- P78423
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Related Signaling Pathways
TNF Signaling Pathway
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Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-2061MZ | Recombinant Mouse Anti-Human CX3CL1 Antibody (clone NN0308-9K34) | IHC-P, WB | Mouse antibody |
| HPAB-1500-FY | Human Anti-CX3CL1 Recombinant Antibody (HPAB-1500-FY) | Neut | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-582CQ | Rat Anti-Cx3cl1 Recombinant Antibody (clone 7F17) | Neut, WB | Rat IgG2 |
| NEUT-583CQ | Mouse Anti-CX3CL1 Recombinant Antibody (clone CBL828) | CyTOF®, ELISA, ICFC, Neut | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0880 | Hi-Affi™ Rabbit Anti-CX3CL1 Recombinant Antibody (clone DS880AB) | ELISA, WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1500-FY-F(E) | Human Anti-CX3CL1 Recombinant Antibody; Fab Fragment (HPAB-1500-FY-F(E)) | Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1500-FY-S(P) | Human Anti-CX3CL1 Recombinant Antibody; scFv Fragment (HPAB-1500-FY-S(P)) | Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY590 | Anti-CX3CL1 Immunohistochemistry Kit | IHC | |
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