Actinobacillus actinomycetemcomitans is one of the most completely studied periodontal bacteria. It stays in the periodontal pocket of the oral cavity and damages tooth supporting tissues. Actinobacillus actinomycetemcomitans is a gram negative bacterium which is spherical or rod-shaped. It's a facultative anaerobe which can grow under either aerobic or anaerobic conditions. Actinobacillus actinomycetemcomitans is a typical cause of periodontitis but it may also be related to systemic infections and arterial plaques. Isolated Actinobacillus actinomycetemcomitans from periodontitis patients releases leukotoxin which kills T cells by some pathways. This will be discussed later in Pathology section. A complete genomic sequence of Actinobacillus actinomycetemcomitans is available in publication by David Dyer, Bruce Roe and colleagues at the University of Oklahoma.