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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease.
Protein class

Plasma proteins

Predicted location


Single cell type specificity

Cell type enhanced (monocytes, Extravillous trophoblasts, Cone photoreceptor cells, B-cells, Plasma cells, Langerhans cells, Rod photoreceptor cells)

Immune cell specificity

Group enriched (eosinophil, basophil, neutrophil, plasmacytoid DC, naive B-cell, memory B-cell)

Cell line specificity

Cell line enhanced (HDLM-2, U-251 MG)


Interacts with SH3PXD2A.

Molecular function

Hydrolase, Metalloprotease, Protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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