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ADGRB3
This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis.
Protein class
G-protein coupled receptors, Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Astrocytes, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (SCLC-21H, SH-SY5Y)
Interaction
Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts (via TSP N-terminal domains) with C1QL1, C1QL2, C1QL3 and C1QL4 (PubMed:21262840). Interacts with ELMO1, ELMO2 AND ELMO3 (PubMed:24567399).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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For Research Use Only. Not For Clinical Use.