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AKR1C1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatocytes, Exocrine glandular cells, Urothelial cells, Cholangiocytes, Basal squamous epithelial cells, Basal respiratory cells, Squamous epithelial cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Group enriched (ASC diff, Hep G2, OE19)
Interaction
Monomer.
Molecular function
Oxidoreductase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Rabbit Anti-AKR1C1 Polyclonal Antibody (MRO-1631-CN) (MRO-1631-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, FC
- Mouse Anti-AKR1C1 Recombinant Antibody (clone 5-F10) (MRO-0041-CN)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a
- Application: WB, IHC, IF, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, ICC, IF
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For Research Use Only. Not For Clinical Use.