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ALKBH2

Anti-ALKBH2 Products

Mouse Anti-ALKBH2 Recombinant Antibody (clone iBCI3-8) (MOB-0399MZ)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-ALKBH2 Recombinant Antibody (VS3-CJ95) (VS3-CJ95)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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Recombinant Rabbit Anti-ALKBH2 Antibody (clone R05-5H7) (VS3-FY67)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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Hi-Affi™ Rabbit Anti-ALKBH2 Recombinant Antibody (clone DS150AB) (MOR-0150)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).

Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with PCNA homotrimer; this interaction is enhanced during the S-phase of the cell cycle (PubMed:19736315, PubMed:26408825, PubMed:23972994). Interacts with nucleolar proteins NCL, UBTF and NPM1 (PubMed:23972994). Interacts with XRCC5-XRCC6 heterodimer (PubMed:23972994).

Molecular function

Dioxygenase, Oxidoreductase

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