Anti-APOA4 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides leading anti-Apolipoprotein A4 (APOA4) recombinant antibodies for gastroenterology and metabolic research studies. APOA4 is a unique apolipoprotein that is made in the gut in response to lipid absorption. Its function is linked to lipid homeostasis, glucose metabolism, and satiety signaling. Our premium rAbs will help you study the role of APOA4 in metabolic syndrome, obesity, and diabetes, to support the development of new therapeutics.

APOA4: A Gut-Derived Signal for Satiety and Glucose Control

Apolipoprotein A4 (APOA4) is an intestinal-specific apolipoprotein that is produced in response to lipid absorption and is loaded into chylomicrons. In addition to their role in lipid transport, the anti-APOA4 rAbs you get from Creative Biolabs will help you study the signaling function of these circulating proteins. APOA4 is a circulating satiety factor, which means that it can reach the brain and induce a decrease in food intake. In addition, it has been shown to have favorable effects on glucose metabolism, enhancing insulin secretion and sensitivity in target tissues. For these reasons, APOA4 is a potential therapeutic target for the treatment of obesity and type 2 diabetes mellitus.

Alternative Names

Apolipoprotein A4; Apolipoprotein A-IV; Apo-AIV; ApoA-IV; APOA4; Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4

Background

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.

Anti-APOA4 rAb Products

Creative Biolabs anti-APOA4 recombinant antibodies are generated for high specificity and sensitivity. The antibodies are fully validated for use in the detection of human and rodent APOA4 and are ready to be applied in a variety of preclinical and translational research applications. The antibodies have high affinity and low background, and our production methods are optimized to ensure the highest quality product for demanding applications such as ELISA and IHC.

Table 1. Featured anti-APOA4 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to quality, and our quality control program is unmatched. We have tight process controls in place at each step of the production process of our anti-APOA4 recombinant antibodies. Each lot is extensively tested to ensure batch-to-batch consistency, purity, binding affinity, and performance in previously validated immunoassays.

Customer Reviews

rAb Production

Creative Biolabs is invested in providing you with antibodies that will help in your groundbreaking research. Our recombinant antibodies are produced on state-of-the-art expression platforms that allow us to generate high-quality antibodies in optimal mammalian cell systems. Antibodies are expressed in such a way to provide correct folding and post-translational modifications that are needed to recognize the native protein. The antibodies are highly active and specific, making them ready for your research.

Featured Anti-APOA4 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-APOA4 recombinant antibody production.

Fig.3 Gram-scale anti-APOA4 recombinant antibody production.

rAb Modalities

Creative Biolabs is here to support your science. Our recombinant antibodies are produced in different formats, including full-length IgGs for functional assays and screening antibody pairs for assay development, providing you the flexibility you need to use these products in a variety of applications. Customize your anti-APOA4 recombinant antibodies with Creative Biolabs today.

Fig.4 Full-length anti-APOA4 recombinant antibody production and modalities.

Explore the many and complex roles of APOA4 in metabolic diseases with Creative Biolabs high quality recombinant antibodies. Our products feature the high specificity, extensive validation, and reliable consistency you need to study this exciting therapeutic target. Contact our team of scientific professionals today.