Loading...
Custom Services order now ship next day

ARTN

This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma.
Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Urothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1)

Interaction

Homodimer; disulfide-linked. Binds to RET (By similarity).

Molecular function

Growth factor

More Types Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare