Anti-ASGR2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your source for premier hepatology and drug delivery research tools, including our portfolio of anti-Asialoglycoprotein Receptor 2 (ASGR2) recombinant antibodies. ASGR2 is a subunit of the major hepatic receptor for galactose-terminated glycoproteins, and is involved in serum protein turnover and homeostasis, making it an attractive target for liver-specific drug delivery systems.

ASGR2: A Subunit of the Liver's Primary Glycoprotein Clearance Receptor

The asialoglycoprotein receptor (ASGPR) is a multi-subunit lectin receptor that is highly and specifically expressed on the surface of hepatocytes. This receptor binds to, internalizes, and clears circulating glycoproteins that have exposed terminal galactose or N-acetylgalactosamine residues. Asialoglycoprotein Receptor 2 (ASGR2) is one of two major subunits. It forms a complex with ASGR1 to form the functional receptor. The liver-specific receptor is primarily responsible for maintaining serum homeostasis by clearing aged or desialylated proteins from the blood. The high specificity of this liver-receptor for the removal of glycoproteins in the liver makes it a useful target for the delivery of drugs, siRNAs, and other therapeutic payloads.

Alternative Names

ASGR2; HBxAg-Binding Protein; ASGP-R 2; Hepatic Lectin H2; HL-2; Asialoglycoprotein Receptor 2; ASGP-R2; ASGPR 2

Background

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Anti-ASGR2 rAb Products

Our anti-ASGR2 recombinant antibodies are engineered and validated to be highly specific and recognize the ASGR2 subunit only, without cross-reactivity to the related ASGR1 receptor subunit. This is critical for studies that focus on subunit composition and function of the asialoglycoprotein receptor. We have optimized our ASGR2 antibodies for flow cytometry and IHC applications to ensure that the rAbs you receive will provide clear and reproducible data for your liver-targeting studies.

Table 1. Featured anti-ASGR2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we utilize state-of-the-art production platforms to help support the rapidly advancing field of targeted drug delivery. Our anti-ASGR2 recombinant antibodies are produced in carefully optimized mammalian systems to express antibodies that specifically recognize the native, extracellular domain of the ASGR2 receptor subunit, ensuring that you receive a product with high biological activity.

Featured Anti-ASGR2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ASGR2 recombinant antibody production.

Fig.2 Gram-scale anti-ASGR2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to helping to drive progress in science by providing researchers with a variety of flexible antibody modalities. We offer our anti-ASGR2 recombinant antibodies in multiple customizable formats, including full-length IgGs to study receptor binding and modified versions for tracking in cells.

Fig.3 Full-length anti-ASGR2 recombinant antibody production and modalities.

Study the biology of the asialoglycoprotein receptor in new ways with Creative Biolabs' anti-ASGR2 recombinant antibodies. Our ASGR2-focused portfolio was designed with subunit-specificity in mind and includes high-quality, rigorously validated antibodies for your research in liver disease and targeted therapeutics. Partner with us for antibody-based solutions that support and drive innovation in your work. Speak to one of our specialists today.