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BCAS3
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For Research Use Only. Not For Clinical Use.
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.
Protein class
Disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Late spermatids, Microglial cells, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (MCF7)
Interaction
Interacts with histone H3, ESR1, KAT2B and PELP1; the interactions occur in a estrogen-dependent manner. Interacts with beta-tubulin and VIM. Interacts (via C-terminal) with PHAF1; the interaction is requrired for the association with the phagophore (PubMed:33499712).
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