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BHLHE41
Loading...Anti-BHLHE41 Products
- Recombinant Mouse Anti-Human BHLHE41 Antibody (MOB-1854MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-BHLHE41 Recombinant Antibody (VS3-FY2635) (VS3-FY2635)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
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- Anti-BHLHE41 Immunohistochemistry Kit (VS-0325-XY240)
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- Species Reactivity: Human, Mouse
- Target: BHLHE41
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Bipolar cells, Rod photoreceptor cells, Horizontal cells, Muller glia cells, Cone photoreceptor cells)
Immune cell specificity
Immune cell enhanced (memory B-cell)
Cell line specificity
Cell line enhanced (hTERT-RPE1, RT4, U-266/70, U-87 MG)
Interaction
Homodimer (By similarity). Heterodimer with BHLHE40/DEC1 (PubMed:15193144). Interacts with CIART and ARNTL/BMAL1 (By similarity). Interacts with RXRA (PubMed:19786558). Interacts with NR0B2 and HNF1A (By similarity).
Molecular function
DNA-binding, Repressor
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