Anti-C1QBP Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, a leader in oncology and virology research, is pleased to offer a new line of premium anti-C1QBP recombinant antibodies (rAbs). As a multifunctional protein with overexpression at the surface of tumor cells, C1QBP (also known as p32) is a novel cancer target of interest. Our superior antibodies are powerful tools for studying its role in oncology, viral infection, and inflammation.

C1QBP: A Multifunctional "Moonlighting" Protein

Mitochondrial C1q Binding Protein (C1QBP), also known as p32 or HABP1, is a “moonlighting” protein of growing interest in cancer, virology, and inflammation research. While it was originally identified in the mitochondria, it localizes to several other cellular compartments, including the nucleus, but of most interest, the cell surface. At the surface of endothelial cells, and the majority of cancer cells, it acts as a receptor for a wide range of ligands including C1q, fibrinogen, viral and bacterial proteins, etc. Its overexpression at the surface of tumors has been linked to increased proliferation, metastasis, and a glycolytic metabolism shift (Warburg effect). Tumor-selective surface expression makes this protein a unique and exciting therapeutic target.

Alternative Names

C1QBP; complement component 1, q subcomponent binding protein; p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R; complement component 1 Q subcomponent-binding protein, mitochondrial; p33; glycoprotein gC1qBP; hyaluronan-binding protein 1; ASF/SF2-associated prot

Background

The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.

Anti-C1QBP rAb Products

Creative Biolabs’ anti-C1QBP recombinant antibodies are designed with unparalleled specificity and reliable performance in mind. Our antibodies are thoroughly validated to specifically detect the C1QBP protein of interest. Optimized for flow cytometry to detect surface expression on cancer cells and IHC to stain tumor tissue, our rAbs are among the best tools for drug discovery in oncology.

Table 1. Featured anti-C1QBP recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To help our customers make meaningful progress in cancer research, Creative Biolabs is applying the latest antibody production technologies. Creative’s anti-C1QBP recombinant antibodies are carefully designed, screened, and selected to provide a high affinity reagent for the cell-surface form of this protein, for therapeutic and diagnostic development.

Featured Anti-C1QBP Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-C1QBP recombinant antibody production.

Fig.2 Gram-scale anti-C1QBP recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to meeting the research community’s needs by providing a variety of antibody modalities. Creative’s anti-C1QBP antibodies are available in many formats, including clones validated for ADC or CAR-T development, so you can conduct your research in the way that is most appropriate for you.

Fig.3 Full-length anti-C1QBP recombinant antibody production and modalities.

Advance your cancer research with Creative Biolabs’ premier anti-C1QBP recombinant antibodies. Creative’s product portfolio is built on our unmatched specificity for this cell-surface target, coupled with extensive validation for performance to create the best tools for your drug discovery work. Place your confidence in us, and contact our specialists today.