Human disease related genes, Plasma proteins
Secreted
Group enriched (Hepatocytes, Alveolar cells type 2, Alveolar cells type 1)
Immune cell enriched (neutrophil)
Cell line enriched (Hep G2)
Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homomer supports tentacles, each with the binding site for C4b at the end. (Microbial infection) Interacts with Staphylococcus aureus protein SdrE; this interaction inhibits complement-mediated bacterial opsonization.
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For Research Use Only. Not For Clinical Use.