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CASQ2

Anti-CASQ2 ProductsBackground
Anti-CASQ2 Products
- Mouse Anti-CASQ2 Recombinant Antibody (clone EML229) (MOB-0295CT)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, WB
- Anti-CASQ2 Immunohistochemistry Kit (VS-0525-XY1016)
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- Species Reactivity: Human
- Target: CASQ2
- Application: IHC
- Anti-Mouse CASQ2 Immunohistochemistry Kit (VS-0525-XY1017)
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- Species Reactivity: Human, Mouse, Rat
- Target: CASQ2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (HSkMC)
Interaction
Monomer, homodimer and homooligomer. Mostly monomeric in the absence of calcium. Forms higher oligomers in a calcium-dependent manner. Dimers associate to form tetramers, that then form linear homomer chains. Interacts with ASPH and TRDN.
Molecular function
Muscle protein
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