CDH13

Anti-CDH13 Recombinant Antibody Products

PE-A*24:02/Human CDH13 (SYLDSGIHF) MHC Tetramer (MHC-LC3296)
- Class: Class I
- Antigen: CDH13
- Antigen Species: Human
- Peptide: SYLDSGIHF
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis.

Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons)

Immune cell specificity

Immune cell enhanced (non-classical monocyte)

Cell line specificity

Cell line enhanced (LHCN-M2, U-138 MG, U-87 MG)

Interaction

By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.

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