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CDK8
Loading...Anti-CDK8 Products
- Recombinant Mouse Anti-Human CDK8 Antibody (MOB-2478MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Rabbit Anti-CDK8 Recombinant Antibody (clone CBACN-143) (MRO-0345-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Rabbit Anti-CDK8 Recombinant Antibody (VS13-YC201) (VS13-YC201)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.
Background
CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Colorectal Adenocarcinoma and Hemophagocytic Lymphohistiocytosis, Familial, 3. Among its related pathways are Signaling by NOTCH1 and Notch Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK19.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons, Late spermatids, Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.
Molecular function
Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
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