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CDNF

Anti-CDNF Products
- Anti-Mouse CDNF Immunohistochemistry Kit (VS-0525-XY1348)
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- Species Reactivity: Mouse
- Target: CDNF
- Application: IHC
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.
Background
Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinsons disease, suggesting that CDNF might be beneficial for the treatment of Parkinsons disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (RPMI-8226, U-266/70)
Molecular function
Growth factor
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