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CHFR
Anti-CHFR Recombinant Antibody Products
- Rabbit Anti-CHFR Polyclonal Antibody (MRO-1773-CN) (MRO-1773-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF
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For Research Use Only. Not For Clinical Use.
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).
Molecular function
Transferase
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