CHRNA7

Creative Biolabs provides a complete spectrum of anti-CHRNA7 recombinant antibodies, enabling researchers to further cancer research. Our products are not only compliant with regulatory requirements but also highly specialized and effective. Furthermore, our first-class support team offers comprehensive technical support services from design to validation to ensure that our antibodies optimize the success of your project.

CHRNA7: A Promising Therapeutic Target for Cancer

The CHRNA7 gene encodes the α7-Nicotinic Acetylcholine Receptor (α7-nAChR), a homopentameric ligand-gated ion channel. Widely expressed in both neuronal and non-neuronal tissues, α7-nAChR plays a multifaceted role in cellular processes, including differentiation, apoptosis, immune responses, and tumorigenesis. Activation of α7-nAChR has been implicated in promoting tumor growth, metastasis, and chemoresistance in various cancers, such as lung, breast, gastric, etc. As a result, targeting CHRNA7 offers a prospective path for the development of new treatment strategies.

Alternative Names

Cholinergic receptor nicotinic alpha 7 subunit; Neuronal acetylcholine receptor subunit alpha-7; nAChRα7; CHRNA7-2, NACHRA7; α7-Nicotinic Acetylcholine Receptor; α7-nAChR.

Background

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Anti-CHRNA7 rAb Products

Creative Biolabs' anti-CHRNA7 recombinant antibodies are precision-engineered for superior specificity and affinity. With a wide array of formats and applications, our products are indispensable for advancing cancer research and accelerating the development of innovative therapeutic approaches.

Table 1. Featured anti-CHRNA7 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is a market leader in antibody development, producing high-quality anti-CHRNA7 antibodies with remarkable specificity and affinity. Each antibody is rigorously tested to ensure optimal performance and dependability across numerous research applications. Our commitment to rigorous quality control enables researchers to access accurate and repeatable data, accelerating cancer research and the development of novel treatment options.

Customer Reviews

Excellent

Je***e
Mouse Anti-CHRNA7 Recombinant Antibody (clone 25A7) (MOB-3814z)

I recently used the anti-CHRNA7 recombinant antibodies from Creative Biolabs in my ELISA assays, and I couldn't be more satisfied with the results. The specificity was impressive, with consistent detection of CHRNA7 across multiple samples. The sensitivity of the assay allowed for the reliable quantification of protein levels, which was crucial for my project. Additionally, the technical support provided by Creative Biolabs was fantastic; they were responsive and helped answer all my questions quickly.

27/Sep/2022

Excellent

Cr***l
Mouse Anti-CHRNA7 Recombinant Antibody (clone mAb 306) (EPAF-0979LC)

I have tried various antibodies for CHRNA7, but the anti-CHRNA7 recombinant antibodies from Creative Biolabs stood out during my ELISA experiments. The quality is exceptional, with clear and reproducible results. The assay showed a low background signal, allowing for accurate measurements. What particularly impressed me was the affordability without compromising on performance.

11/Feb/2024

rAb Production

Creative Biolabs offers custom-made anti-CHRNA7 antibodies using advanced recombinant technology to support scientific research and discoveries.

Featured Anti-CHRNA7 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CHRNA7 recombinant antibody production.

Fig.2 Gram-scale anti-CHRNA7 recombinant antibody production.

rAb Modalities

Creative Biolabs offers a wide range of well-performance anti-CHRNA7 recombinant antibodies in plenty of formats to assist customers with their meaningful projects.

Fig.3 Full-length anti-CHRNA7 recombinant antibody production and modalities.

CHRNA7-Targeted Drug Information

Table 2. Public drug targeting CHRNA7.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs stands at the forefront of antibody innovation, blending comprehensive scientific expertise with practical application. Our premium anti-CHRNA7 antibodies are meticulously crafted to fulfill the stringent demands of contemporary research. Reach out to us to explore our diverse range of products and learn how our tailored antibody solutions can enhance your research endeavors.