FDA approved drug targets, Human disease related genes, Transporters
Membrane
Cell type enhanced (Inhibitory neurons, Gastric mucus-secreting cells, Horizontal cells, Proximal enterocytes, Excitatory neurons)
Not detected in immune cells
Cell line enhanced (AN3-CA, RT4, SH-SY5Y, SK-BR-3, U-2 OS)
Homopentamer (By similarity). Interacts with RIC3; which is required for proper folding and assembly (PubMed:15504725, PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). Interacts with the alpha-conotoxin RgIA (By similarity). Interacts with alpha-conotoxins ImI and ImII (PubMed:15609996). Interacts with CANX (PubMed:32783947).
Ion channel, Ligand-gated ion channel, Receptor
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For Research Use Only. Not For Clinical Use.