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CLCN4

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For Research Use Only. Not For Clinical Use.


CLCN4 (Chloride Voltage-Gated Channel 4) is a Protein Coding gene. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Diseases associated with CLCN4 include Raynaud-Claes Syndrome and Non-Syndromic X-Linked Intellectual Disability.
Protein class

Disease related genes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Bipolar cells, Oligodendrocytes, Inhibitory neurons, Horizontal cells, Excitatory neurons, Rod photoreceptor cells)

Immune cell specificity

Immune cell enhanced (naive B-cell, neutrophil)

Cell line specificity

Cell line enhanced (GAMG, HEL, SCLC-21H)

Interaction

Monomer (PubMed:28972156). Forms heterodimers with CLCN3 (PubMed:28972156).

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