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CRACR2A
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For Research Use Only. Not For Clinical Use.
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Intestinal goblet cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
[Isoform 1]: Interacts with ORAI1 and STIM1; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with ORAI1 and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with ORAI2 and ORAI3. [Isoform 2]: Interacts with DYNC1H1 (PubMed:31092558). Interacts with the dynein-dynactin complex in a Ca(2+)-dependent manner (PubMed:30814157). Interacts with VAV1 (PubMed:27016526).
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