Anti-CYP3A4 Products

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Creative Biolabs is your expert partner in pharmacology. Our elite anti-CYP3A4 recombinant antibodies are the highest quality tools for studying drug-drug interactions, pharmacokinetics and clinical trial success.

CYP3A4: The Most Important Human Drug Metabolizer

Cytochrome P450 3A4 (CYP3A4) is a monooxygenase enzyme present in the endoplasmic reticulum of the liver and small intestine. It is the most abundant of the human CYP enzymes and it catalyzes the phase I metabolism of nearly 50% of all prescription drugs, including statins, macrolide antibiotics, and benzodiazepines. CYP3A4 can accept a wide range of substrates due to its large, flexible active site. Due to its high potential for drug-drug interactions (DDI) and its extensive genetic variability, the activity of this enzyme is extremely important to understand in order to design safe and effective drug regimens.

Alternative Names

Glutamic-Oxaloacetic Transaminase 2; Kynurenine Aminotransferase IV; Plasma Membrane-Associated Fatty Acid-Binding Protein; Glutamic-Oxaloacetic Transaminase 2, Mitochondrial; Kynurenine--Oxoglutarate Transaminase IV; Kynurenine--Oxoglutarate Transaminase 4; Glutamate Oxaloacetate Transaminase 2; Kynurenine Aminotransferase 4; Aspartate Aminotransferase 2; Fatty Acid-Binding Protein; Aspartate Transaminase 2; Transaminase A; EC 2.6.1.1; CYP3A4; Aspartate aminotransferase; mitochondrial; mAspAT; Fatty acidbinding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynu

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Anti-CYP3A4 rAb Products

Our anti-CYP3A4 recombinant antibodies are engineered for high specificity and are carefully validated to accurately detect the CYP3A4 enzyme in your samples, with selectivity even over the highly homologous CYP3A5 and CYP3A7. Optimized for use in Western Blot of liver microsomes, IHC, and in development of drug inhibition assays, our rAbs are designed to offer the reliability and precision required in advanced pharmacological research.

Table 1. Featured anti-CYP3A4 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs takes scientific quality very seriously. The manufacturing of our anti-CYP3A4 recombinant antibodies is regulated by a rigorous quality assurance system. Every lot is validated and tested for purity, high isoform specificity, and consistent performance in validated applications.

Fig.1 IHC analysis of anti-CYP3A4 antibody
(Cat# ZG-0632J, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is proud to support the specialized scientific field of pharmacology with its state-of-the-art production platforms. Our anti-CYP3A4 recombinant antibodies are expressed in optimized systems that ensure the recognition of the native enzyme and a specific, active research tool.

Featured Anti-CYP3A4 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CYP3A4 recombinant antibody production.

Fig.3 Gram-scale anti-CYP3A4 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to supporting scientific progress by providing a wide range of flexible antibody solutions. Our anti-CYP3A4 recombinant antibodies are available in a variety of customizable modalities, so you can find the right tool for your research needs.

Fig.4 Full-length anti-CYP3A4 recombinant antibody production and modalities.

Dissect the mechanisms of metabolism with superior anti-CYP3A4 recombinant antibodies from Creative Biolabs. Our comprehensive portfolio features the validated specificity you need to study this key drug metabolizer enzyme in drug development and clinical pharmacology. Trust Creative Biolabs to provide the foundation for your research. Connect with our experts today.