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CerS5

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For Research Use Only. Not For Clinical Use.


Background

CERS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CERS5 expression is elevated. Upon knocking down acid sphingomyelinase and CERS5 in NTERA-2cells, Bax localization to mitochondria was reduced, indicating the importance of CERS5 activity in the apoptosis pathway.
Protein class

Enzymes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Molecular function

Transferase

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