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DPY30
Loading...Anti-DPY30 Products
- Mouse Anti-DPY30 Recombinant Antibody (clone 1-6) (MRO-0493-CN)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IF
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- Rabbit Anti-DPY30 Polyclonal Antibody (MRO-1823-CN) (MRO-1823-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Respiratory ciliated cells, Endometrial ciliated cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
Molecular function
Chromatin regulator
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