+ Filter
Loading...
DUX4
Loading...Anti-DUX4 Products
-
- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: ICC, IF, WB, FC
Compare
- Anti-DUX4 Immunohistochemistry Kit (VS-0525-XY2116)
-
- Species Reactivity: Human
- Target: DUX4
- Application: IHC
Compare
- Anti-Mouse DUX4 Immunohistochemistry Kit (VS-0525-XY2117)
-
- Species Reactivity: Human, Mouse
- Target: DUX4
- Application: IHC
Compare
More Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Potential drug targets, Transcription factors, Transporters
Predicted location
Intracellular
Single cell type specificity
Group enriched (Late spermatids, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A549, U-2 OS, U-266/70, U-266/84, U-698)
Interaction
Binds DNA as a monomer (PubMed:30322619, PubMed:30540931). Interacts (via C-terminus) with EP300 and CREBBP (PubMed:26951377).
Molecular function
Activator, Developmental protein, DNA-binding
More Types Infomation