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EDNRB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Sertoli cells, Astrocytes, Adipocytes, Muller glia cells, Hepatic stellate cells, Melanocytes, Smooth muscle cells, Skeletal myocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, ASC diff, SK-MEL-30, U-266/70, WM-115)
Molecular function
G-protein coupled receptor, Receptor, Transducer
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