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EFNA1

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis.
EFNA1
Protein class

Cancer-related genes, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts)

Immune cell specificity

Group enriched (naive CD4 T-cell, naive CD8 T-cell)

Cell line specificity

Cell line enhanced (BEWO, HaCaT, SiHa, SK-BR-3)

Interaction

Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.

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