


EGLN3

Anti-EGLN3 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
- Anti-EGLN3 Immunohistochemistry Kit (VS-0325-XY736)
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- Species Reactivity: Human, Mouse, Rat
- Target: EGLN3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Enzymes
Intracellular
Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Distal enterocytes, Extravillous trophoblasts, Cardiomyocytes)
Immune cell enriched (plasmacytoid DC)
Cell line enhanced (RH-30, RPTEC TERT1, RT4)
Interacts with BCL2 (via its BH4 domain); the interaction disrupts the BAX-BCL4 complex inhibiting the anti-apoptotic activity of BCL2 (PubMed:20849813). Interacts with WDR83; the interaction leads to almost complete elimination of HIF-mediated reporter activity (By similarity). Interacts with ADRB2; the interaction hydroxylates ADRB2 facilitating its ubiquitination by the VHL-E3 ligase complex (PubMed:19584355). Interacts with PAX2; the interaction targets PAX2 for destruction (PubMed:21575608). Interacts with PKM; the interaction hydroxylates PKM in hypoxia (PubMed:21620138, PubMed:21483450). Interacts with LIMD1, WTIP and AJUBA (PubMed:22286099).
Dioxygenase, Oxidoreductase