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EPHA1
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For Research Use Only. Not For Clinical Use.
Background
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Squamous epithelial cells, Early spermatids, Gastric mucus-secreting cells, Proximal enterocytes)
Immune cell specificity
Group enriched (naive CD4 T-cell, naive CD8 T-cell, memory CD4 T-cell)
Cell line specificity
Cell line enhanced (CACO-2, HaCaT, HBEC3-KT, MCF7, NTERA-2)
Interaction
Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
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