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EPHA6

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For Research Use Only. Not For Clinical Use.


Background

EPHA6 (EPH Receptor A6) is a Protein Coding gene. Diseases associated with EPHA6 include Oculoauricular Syndrome. Among its related pathways are Development Slit-Robo signaling and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Excitatory neurons, Astrocytes, Early spermatids, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HEK93, U-266/70)

Interaction

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via SAM domain) with ANKS1A (via SAM domain) (By similarity).

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

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