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ERP44
Loading...Anti-ERP44 Products
- AbPlus™ Anti-ERP44 Magnetic Beads (VS-0724-YC855) (VS-0724-YC855)
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- Target: ERP44
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-ERP44 Immunohistochemistry Kit (VS-0525-XY2361)
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- Species Reactivity: Human
- Target: ERP44
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms mixed disulfides with both ERO1A and ERO1B and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration (By similarity).
Molecular function
Chaperone
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