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    ETS1

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    Anti-ETS1 Recombinant Antibody Products

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
    Protein class

    Plasma proteins, RAS pathway related proteins, Transcription factors

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (NK-cells, dendritic cells, T-cells, Adipocytes, Hepatic stellate cells, Endothelial cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (HEL, JURKAT, U-698)

    Interaction

    Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.

    Molecular function

    DNA-binding

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