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EZH1

Anti-EZH1 Products

Hi-Affi™ Rabbit Anti-EZH1 Recombinant Antibody (clone DS1220AB) (MOR-1220)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, IP, WB, ICC, IF
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Mouse Anti-EZH1 Recombinant Antibody (clone 4B11B4) (VS7-HM919)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FCM
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Mouse Anti-EZH1 Recombinant Antibody (clone 3B6B9) (VS7-HM920)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FCM
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More Infomation

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For Research Use Only. Not For Clinical Use.

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity.

Protein class

Cancer-related genes, Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Rod photoreceptor cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (ASC diff)

Interaction

Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2 (PubMed:19026781). The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM) (PubMed:19026781). Interacts with EZHIP; the interaction blocks EZH1 methyltransferase activity (PubMed:31451685).

Molecular function

Chromatin regulator, Methyltransferase, Repressor, Transferase

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