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FLRT3
Loading...Anti-FLRT3 Products
- Rabbit Anti-Flrt3 Recombinant Antibody (clone rN353/13) (VS-0422-LC13)
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ICC
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- Mouse Anti-Flrt3 Recombinant Antibody (clone mN353/13) (VS-0422-LC12)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: ICC
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- Mouse Anti-FLRT3 Recombinant Antibody (clone 1.4.1) (FAMAB-0548WJ)
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Basal prostatic cells, Alveolar cells type 2, Club cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, hTCEpi, RPTEC TERT1, WM-115)
Interaction
Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).
Molecular function
Developmental protein
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