Membrane
Cell type enhanced (Skeletal myocytes, Oligodendrocyte precursor cells, Fibroblasts, Hepatocytes, Astrocytes, Breast glandular cells)
Not detected in immune cells
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, EFO-21, fHDF/TERT166, HBF TERT88, MCF7, U-251 MG)
2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET (By similarity). Interacts with RET (PubMed:23333276). Interacts with SORL1, either alone or in complex with GDNF (PubMed:23333276). Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation (PubMed:23333276).
Receptor
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For Research Use Only. Not For Clinical Use.