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GGA2
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, U-698)
Interaction
Monomer (Probable). Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3 (PubMed:14638859). Binds to clathrin and activated ARFs, such as ARF1, ARF5 and ARF6 (PubMed:11301005, PubMed:11950392). Binds RABEP1 and RABGEF1 (PubMed:12505986). Interacts with the type-I membrane proteins LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 (PubMed:11390366, PubMed:11387475, PubMed:11886874, PubMed:14567678). Interacts (via N-terminal VHS domain) with SORL1/sorLA and SORT1 (via C-terminal cytosolic domain) (PubMed:11331584, PubMed:11390366, PubMed:11821067). Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2 (PubMed:10814529, PubMed:12429846, PubMed:12808037, PubMed:14665628). Interacts with ADRA2B (PubMed:27901063). Interacts (via VHS domain) with PIK4B; the interaction is important for PIK4B location at the Golgi apparatus membrane (PubMed:28289207).
More Types Infomation
- PE-A*31:01/Human GGA2 (YLGSWATGK) MHC Tetramer (MHC-LC4481)
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- Class: Class I
- Antigen: GGA2
- Antigen Species: Human
- Peptide: YLGSWATGK
- Conjugate: PE
- PE-A*11:01/Human GGA2 (YLGSWATGK) MHC Tetramer (MHC-LC4480)
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- Class: Class I
- Antigen: GGA2
- Antigen Species: Human
- Peptide: YLGSWATGK
- Conjugate: PE
- PE-A*03:01/Human GGA2 (YLGSWATGK) MHC Tetramer (MHC-LC4479)
-
- Class: Class I
- Antigen: GGA2
- Antigen Species: Human
- Peptide: YLGSWATGK
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.