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GRM3

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For Research Use Only. Not For Clinical Use.


G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Protein class

G-protein coupled receptors

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Oligodendrocytes, Astrocytes, Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (AF22)

Interaction

Interacts with TAMALIN.

Molecular function

G-protein coupled receptor, Receptor, Transducer

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