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HBG1
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Protein class
Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Macrophages)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (K-562)
Interaction
Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). In the case of deletions affecting one or more of the alpha chains, the excess gamma chains form homotetramers that exhibit neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's).
More Types Infomation
- Mouse Anti-HBG1 Recombinant Antibody (clone 7G4) (MOB-2394z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, IHC
- Rabbit Anti-HBG1 Recombinant Antibody (clone JM84-10) (MRO-0730-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.