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HLA-DOA
Loading...Anti-HLA-DOA Products
- Recombinant Anti-Human HLA-DOA Antibody Fab Fragment (MOB-2677z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, FuncS
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- Recombinant Anti-Human HLA-DOA Antibody scFv Fragment (MOB-2677z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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For Research Use Only. Not For Clinical Use.
Background
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (B-cells, Langerhans cells, monocytes, Macrophages, Alveolar cells type 2, Kupffer cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (naive B-cell, myeloid DC)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, REH, U-698)
Interaction
Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.
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