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HLA-F
Anti-HLA-F Recombinant Antibody Products
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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- Mouse Anti-HLA-F Recombinant Antibody (clone 3F11F4) (VS7-0425-WR73)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, FC
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- Mouse Anti-HLA-F Recombinant Antibody (clone 3D10H2) (VS7-0425-WR74)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (NK-cells, Proximal enterocytes, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431, GAMG, HEK93, HEL, HHSteC, JURKAT, U-266/70, U-937)
Interaction
Forms a heterotrimer with B2M and a self-peptide (PubMed:28636952). Binds a diverse number of peptides ranging from 7 to more than 30 amino acids (PubMed:28636952). Peptide-bound HLA-F-B2M interacts with LILRB1 and LILRB2 but not with KIR3DS1 or KIR3DL2; this interaction is direct (PubMed:28636952, PubMed:11169396). The OC form interacts with KIR3DS1, KIR2DS4 and KIR3DL2; this interaction is direct (PubMed:28636952, PubMed:27455421, PubMed:24018270). Interacts with TAP1-TAP2 complex and CALR; this interaction is required for appropriate folding and peptide loading (PubMed:10605026, PubMed:11169396). Interacts with the coat protein complex II and 14-3-3 proteins; these interactions likely control the anterograde ER-to-Golgi transport of HLA-F (PubMed:16709803). HLA-F-B2M complex interacts with the heavy chain of other MHC class I molecules including HLA-A and HLA-E; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I OCs (PubMed:20483783).
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