Anti-HSD17B8 Recombinant Antibody Products

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Anti-HSD17B8 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs leads the development of advanced HSD17B8-targeting antibodies that transform biomedical discovery through next-generation protein engineering. Our proprietary platform combines innovative structural design with multi-tiered quality validation, producing research-grade reagents that establish new benchmarks in specificity and reproducibility. Scientists benefit from our carefully developed portfolio of optimized antibodies, each precisely engineered to address complex experimental needs across diverse therapeutic areas. We enhance this offering through personalized scientific collaboration – providing customized experimental design, technical troubleshooting, and ongoing optimization to maximize research outcomes. This unique combination of premium antibody tools and dedicated scientific partnership creates an ideal environment for converting innovative ideas into significant discoveries.

HSD17B8: A Pivotal Enzyme in Hormone-Dependent Cancers and Metabolic Disorders

HSD17B8 plays a pivotal role in multiple disease pathways through its unique enzymatic functions in steroid and fatty acid metabolism. This mitochondrial protein's abnormal activity contributes to endocrine-related malignancies, particularly influencing hormone-sensitive cancers through altered steroid hormone conversion. Its involvement in neurosteroid metabolism links dysregulation to neurodegenerative conditions, with altered expression patterns observed in Alzheimer's disease patients. The enzyme's dual role in lipid homeostasis connects its dysfunction to metabolic disorders, potentially exacerbating insulin resistance and dyslipidemia. In cancer biology, abnormal expression correlates with tumor progression in various malignancies, likely through both hormonal and non-hormonal mechanisms affecting cell proliferation. Structural studies reveal unique substrate-binding characteristics that could be exploited for targeted therapies, though challenges remain in developing tissue-specific modulators. The protein's participation in mitochondrial β-oxidation suggests additional implications for energy metabolism disorders and age-related degenerative processes. Recent research highlights its potential as a biomarker for disease progression in both metabolic and neurological conditions, while its complex regulation presents multiple therapeutic intervention points. The growing understanding of its multifunctional nature continues to reveal novel associations with diverse pathological states across multiple organ systems.

Alternative Names

Complement HSD17B8; KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9

Background

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.

Anti-HSD17B8 rAb Products

Our mission is to propel scientific research forward by delivering premium recombinant anti-HSD17B8 antibodies, cost-efficient solutions, and reliable expert support, all designed to empower researchers and facilitate impactful discoveries in their respective fields.

Table 1. Featured anti-HSD17B8 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

Br**n
Rabbit Anti-HSD17B8 Recombinant Antibody (clone DS1682AB) (CAT#: MOR-1682)

For Western blot analysis using lysates from MCF7 cells, we employed the Rabbit Anti-HSD17B8 Recombinant Antibody. The antibody successfully detected a distinct, specific band at the anticipated molecular weight, accompanied by minimal background noise. It performed effectively with our standard blocking and washing protocols, making it a reliable and robust choice for consistent Western blot detection in such experimental setups.

18/Feb/2024

Excellent

M**re
Rabbit Anti-HSD17B8 Recombinant Antibody (clone DS1682AB) (CAT#: MOR-1682)

For our Western blot experiments, we used the Rabbit Anti-HSD17B8 Recombinant Antibody on lysates from HepG2 cells. The antibody gave a strong, specific signal with minimal background interference. It performed consistently across replicates and fit well into our existing WB protocol. Overall, we found it to be a dependable reagent for HSD17B8 detection.

22/Aug/2024

rAb Production

Backed by extensive experience in recombinant antibody development, we focus on providing reliable, top-grade products with speed and precision. Our dedication to quality supports timely delivery and consistent customer support throughout the process.

Featured Anti-HSD17B8 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs provides an extensive selection of cutting-edge recombinant antibodies in diverse configurations, empowering researchers across multiple disciplines. Through our mastery of advanced antibody development technologies, we create adaptable biological tools optimized for various research applications. Additionally, our specialists offer bespoke engineering solutions complemented by professional consultation to precisely meet your project's unique requirements and challenges.

Fig.3 Full Length Anti-HSD17B8 Recombinant Antibody Production and Modalities.

For comprehensive information regarding the HSD17B8 target, our scientific support specialists are available to assist you via phone or email. We encourage you to connect with our experts who can provide tailored solutions to address any experimental challenges, ensuring your research progresses smoothly toward achieving its objectives - please feel free to get in touch with us at any time.