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HTR4
Loading...Anti-HTR4 Products
- AbPlus™ Anti-HTR4 Magnetic Beads (VS-0724-YC1331) (VS-0724-YC1331)
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- Target: HTR4
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-HTR4 Immunohistochemistry Kit (VS-0525-XY3355)
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- Species Reactivity: Human
- Target: HTR4
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Protein class
FDA approved drug targets, G-protein coupled receptors
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).
Molecular function
G-protein coupled receptor, Receptor, Transducer
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